AMROrbit

Our World in AMR

Antimicrobial resistance is evolving faster than our defenses. AMROrbit redefines our approach by transforming routine antimicrobial susceptibility testing data into dynamic, easy-to-interpret scorecards. Our innovative scorecard tracks resistance trends over time and across geographies, categorizing them into intuitive zones that highlight emerging risks and provide actionable insights.

By unlocking the untapped potential of everyday diagnostics, the AMROrbit Scorecard empowers governments, healthcare leaders, and policymakers to identify critical areas needing immediate attention and move from reactive responses to proactive, anticipatory strategies.

Scorecards

The AMROrbit Scorecard is a unique tool designed to empower governments globally in the rigorous monitoring and management of antimicrobial resistance (AMR). The Scorecard presents a phase-space plot with resistance levels on the x-axis and the rate of change on the y-axis. Countries in the bottom-left quadrant display favorable AMR profiles, characterized by low initial resistance and a slow increase over time. The remaining quadrants identify countries where targeted interventions are needed due to rising resistance, high baseline resistance, or both.

Surrogate Indicators

Cross-correlation analysis, including lead/lag analysis, was employed to assess the temporal relationships between resistance patterns across different antibiotics. These surrogate indicators act as early warning signs, offering valuable insights for timely intervention and strategic decision-making in combating antimicrobial resistance. Our study identified antibiotic coupling at the global level, which can be further mined to guide and optimize surveillance strategies.

Genomic Models

Bayesian Networks (BNs) were utilized to model the conditional dependencies between antibiotic resistance patterns and genomic data. This approach allows for understanding the relationships between genetic factors and resistance.